Original, Exclusive Provider of Minicircle's Follistatin Plasmid Gene Therapy Since 2022.

Patient Application for Procedure
  • Safety Documented in Safety Study
    *Click here to read the first publication
  • Recombinant DNA technology is utilized by plasmid vectors
    *Recombinant DNA technology has been around for decades and provides some of the most utilized pharmaceuticals:  insulin, growth hormone, and even anti-venom
    *Plasmid vectors do NOT incorporate into a patient’s chromosomal DNA; they are non-heritable and non-permanent
  • Follistatin plasmid gene therapies can help improve bone density & lean muscle mass
  • Follistatin plasmid gene therapies can help lengthen telomeres, possibly increasing longevity

Background Information for Plasmid Therapies

Plasmid therapies have been used in medicine for several decades.  For example, insulin, human growth hormone, snake anti-venom, and several other critical medications are produced using plasmids from the bacterium E. coli in a process known as recombinant DNA technology.

What is a plasmid?

Here is a link to a short video clip that illustrates the basic construction and recombinant capabilities of plasmids: 
https://blog.addgene.org/plasmids-101-what-is-a-plasmid

Below is a graphic of a plasmid (circular piece of DNA) that has been transformed by gene insertion:

Here is an graphic illustrating the process of utilizing plasmids in making insulin for human use:

Another example:

For years, plasmids have been used to safely & effectively manufacture products for human use in medicine. 

Minicircle is using plasmid carriers (instead of viral vectors) to place recombinant DNA (gene coding for follistatin) plasmids inside human cells. The plasmids migrate to the nucleus, where they DO NOT incorporate into the cells’ chromosomal DNA.  The plasmids are temporary. In addition, the plasmid’s presence in the nucleus of the human cell is temporary, lasting only months.  For the purposes of this study, the safety and efficacy of the expression of the gene for human follistatin will be studied.

Incorporation of a recombinant plasmid into a human cell & nucleus:

“The benefits of follistatin plasmid gene therapy can help increase a patient’s quality of life during the aging process, and may even help reverse or slow the biologic aging process. Gene therapies, in my opinion, hold a great deal of promise for the future of medicine and we are thrilled to work with Minicircle in the endeavors to ethically help provide patients access to the latest safe and effective treatment options,”  Glenn C. Terry, M.D.

Coming soon!  Minicircle’s Klotho Plasmid Gene Therapy

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